I’m praying for Mr. Ledermann and his family.
Peter Lederman in Second Bout With COVID-19
I saw on Facebook late last night that Mike Fremer told one of his Audio Friends that he heard from Peter Lederman of Soundsmith that he is suffering his second round with COVID. Peter said he has blood clots on his lungs. That is all the post said. Here is hoping that Peter pulls through with a full recovery.
502 responses
All - it’s illegal and unethical to discuss in a public forum someone’s health issues by sharing private medical details and making speculations on his health. It's not illegal to discuss the state of someone's health. Unethical is your opinion. Now if someone was sharing his medical chart, or one of his healthcare providers was disclosing information, that would be a different story. Nobody has shared "private" medical details. If you read the original post, Peter shared his medical condition with a member of the media. |
As a former virologist - it would be extremely unusual for Peter to have a bad secondary infection so close to the first...We also don't know his vaccine status. A doctor at UCLA who follows long haul COVID patients has observed - as have others - that treatment with the vaccine after infection helps a significant percentage of those suffering symptoms (of course if they have not been vaccinated) - up to 40%. That's been noted by others as well, and has benefited a higher percentage of patients in a few unpublished studies so far than any of the MAbs. I wish Peter well, and hope he is at a good research hospital where they can get him the best care. If not, perhaps he should consider transferring? And gets his vaccine(s). |
What @lewm said. @dover1, there was no validation that there was a "gain of function" research that led to SARS CoV-2019. Had the virus been completely engineered, there would be easily discernable "splice" sites that could be detected on sequencing, and we don't see that. Yes, this SARS virus can recombine, but not nearly as much as flu does (hence why we require shots every year). Also, flu mutates much more rapidly, as lewm observed because of SARs' proof reading ability. In any case, most mutations would be neutral or inhibitory to virus' s infectiousness and replication, so there's that. Yes, China hasn't been completely transparent, and we may never know exactly what happened, but best evidence is that this wasn't engineered. None of this helps Peter though, and I really hope he is getting the best care from experts - I also like teaching hospitals. Please let us know if there is anything we can do, in addition to buying more Soundsmith :-) - do we know the hospital? Can we send him cards, flowers, etc.? |
My family's best wishes to Peter, his family, and his crew at Soundsmith. Peter is a very nice person and they don't often make them like that anymore! Hey Peter, if you are listening, stay healthy and happy! The audioworld is rooting for you to beat Covid (again), and making more fine Soundsmith stylus cartridges! |
MillerCarbon-- By every significant biological metric the US healthcare system is in dire need of some care itself. As in code-blue. No other wealthy country on this planet puts its own people through the BS this system by and large does. And at mafia-pricing no less. Worst outcomes, most expensive-- by a lot. This has been a growing problem and it is what it now is. I agree, get Peter home ASAP if at all possible. The environment itself is soul-depressing, unhealthy. And this is not to criticize the many many good and wonderful people that work their asses off in our system-- the problem IS the system. And they know it all too well. Hang in there Peter -- the world needs you and you have much more to teach! |
the problem IS the system. And they know it all too well. Yes the problem IS the system. But I am not so sure that they know it. The entire population seems to be under the delusion that we no longer need to think for ourselves, and indeed that it is questionable to do so, and that we must simply do whatever we are told to do. One example, I can give dozens but just one, a guy walks in with a dislocated shoulder. You can see from across the lobby it is dislocated. The patient says, "I dislocated my shoulder." Not the first time either. It is a freaking dislocated shoulder, okay? He needs to go to the ER. He even knows this, was just hoping to save some time, pain and agony, and money. He is a working man still thinking for himself still assuming the system is comprised of thinking individuals. Like, you know, it used to be. Fortunately I am up front and say yeah you need to go to the ER. Because the other one who is supposed to be there is trained to check him in, waste his time, and then an hour later a doc will tell him we can’t do that you need the ER. This is corporate policy. When I lay this out for one of our "providers" (which is the term they use to obfuscate the fact you are not seeing an actual MD) and ask if she thinks this sounds like good health care, she looks at me like I’m from Mars. "What is this "think" he is talking about? I don’t know this word, "think". It sounds vaguely disturbing." Its not like the US is the worst either. In Canada they get "free" health care that everyone pays massive taxes for. They have last time I looked about 1/4 the CT machines per capita as here in the US. I personally have seen patients come in with a broken hip, x-rayed their hip in the AM, and been in the OR the same day with the same patient getting it pinned. Personally witnessed broken hips being operated on the same day. In Canada the wait can be days, weeks, months. Where I am fairly close to the border we got Canadian patients in all the time paying for stuff they couldn't get done back home without waiting forever, and ever. In the UK when the ER wait times got into more hours than they wanted the simply refused to let ambulances bring patients in. So they wait in the parking lot instead of the ER. I could go on and on with examples. I could tell you all what is wrong but nobody understands markets, economics, and everyone is mentally MF’d into arguing all the narrative talking points plus of course the aforementioned inability to think at all any more. So all I will do is reiterate to never set foot in a hospital unless you absolutely must, and then beat tracks out of there as fast as you can, all the while telling yourself the whole time the doctor is talking, "This guy is lying, he is lying, lying, lying to me. Oh God there he goes again lying. Liar liar healthcare’s on fire." |
I can agree with some of your sentiments, but the last paragraph is scurrilous. The problem with US medicine is the fact that the big medical corporations and the insurance companies DO understand economics, and they have f**ked up the practice of medicine for idealistic doctors who want to do right but are prevented many times by their system from following the course of action they would prefer, because of the almighty dollar. For example, insurance companies hire medically ignorant persons to make decisions about paying for care. They do this because the first duty of their front line personnel is to say no, and then see how hard they are pushed by the doctors to make the insurance company pay for the procedure in question. Threats of law suits are often required. I know you prefer to hate everyone, because no one has the obvious common sense that you believe you alone possess. |
A 4/6/21 post from Audionirvana: Hi everyone, This is John from Soundsmith. I wanted to let you know that Peter is recovering at home now and will be convalescing for some time. That means he will be out of touch with people for a while. This is great news to all that have posted on this site. Keep on praying for him, he's coming out of the woods, but it will be some time before total recovery. |
There is no more expensive or worse performing healthcare system in the developed world than the one we have here in the good'ol USA. This is a long-documented fact and the accumulated data in incontrovertible. Canadians do pay more in taxes that include full healthcare services (for non-discretionary care) but that amounts to far less money per year spent by individuals and families-- A LOT LESS MONEY. There are no onerous co-pays, deductibles, out-of-network charges, (now a racket here in the USA), and wasted time. MillerCarbon -- the US system (save for the VA) is a private and largely "for-profit" system run by corporate predators. MediCare is a hybrid system with the government controlling payments for privately rendered services. There are no rational or logical explanations that explain the cost differentials here vs. everywhere else other than price gouging and market manipulation. I have seen other systems in other countries and know how they work-- compared to France, England, Germany, and Demark-- the ones I'm familiar with-- ours is a very bad and a very sad joke. I'm sure we can all think of someone that went through the US healthcare meatgrinder and profit extractor of a system and either ended up dead, worse off, broke, or some combination of the above. If most Americans actually knew just how badly they were being screwed over by our system they would be livid. Trying not to think about it is a defense for many-- but that won't help you much when you really need it. As far as comments on COVID being an over-blown hoax with a death rate (didn't Kurt Russel star in that movie?) that was cribbed from other categories of mortality-- that is just not true. This theory was examined by scientists and epidemiologists and rejected. COVID was the third leading cause of death in the US in 2020 (and maybe even 2021) just under heart disease and cancer-- but those are diseases that often take decades to play out. Although I often appreciate MillerCarbon's passion for audio, his skepticism, and humor, he's got some of it wrong with respect to COVID. It is not a killer that hides in the background noise of public health data-- it's one of the most lethal viruses ever to infect humans-- because it is so contagious and because it can hide and spread wildly through asymptomatic people. It also leaves behind loads of long-lasting to permanent chronic problems. Compared to the common flu-- COVID is more than one order of magnitude more lethal. Never forget that. Don't believe the politicized arguments-- just follow the science and public health data and then make your mind up. |
From YouTube.. The Results are in. The US FDA Knows Leronlimab Saves Lives! https://youtu.be/uEdHSu1FUt0 The same company is also running tests with this same drug for long haulers those who have recurring issues after their initial recovery from covid. My wife and I both received our 2nd Pfizer vaccine an hour ago. Stay well everyone. Tom |
millercarbon, Did you ever thank people in the hospital who saved your life and enabled you to continue insulting them on the Internet? Someone stayed up all night to make sure you did well. They actually risked their lives to help you. And what good did you do? Being abusive to them is not nice while posting the link to your, in reality, worthless audio system with pride virtually every day. Let me remind you how you felt while they worried about you... "I was at one point on 10 liters 02, which is a lot of oxygen, and even at that out of breath and feeling like I was about 10 feet underwater. That’s just lying there. Just to roll over, adjust blankets, was an effort it took a while to recover from. How close I was to being on a vent, I don’t want to know. Too close for comfort." |
"Personally witnessed broken hips being operated on the same day. In Canada the wait can be days, weeks, months." "For hip fracture repair, 88 per cent of Canadians were treated within the 48-hour benchmark time, while 64 per cent of B.C. patients made the target." B.C. patients wait longer for key medical procedures than other Canadians, report suggests | CBC News |
theaudiotweak, "Glupson there are results in the Philippines now. Why dont you look?" I did. I looked and they are not worth much yet. The success they are claiming was 100% (without even accounting for other possible factors and very unclear what criteria "improvement" met). The sample size was.....one. If it were April 1st, you could think someone is joking. CytoDyn Providing Leronlimab to a Philippine Hospital for 28 More COVID-19 Patients under Compassionate Special Permit (CSP) :: CytoDyn Inc. (CYDY) Having said all of that, I am keeping fingers crossed that it actually works as advertised. |
A previous trial with the FDA was for 2 doses, the manufacturer requested a trial with 4 doses. Now there is to be a redo...Makes me wonder why the FDA over ruled the people that designed the drug..Leronlimab. The power of this molecule is reported to be a potent drug in the fight against HIV and some types of cancer. Maybe big drug firms are frightened by this molecule and want to mute the company or buy it up so as to continue with their sales of wares which are less effective. I hope not... People are still very ill and many are still dying here and everywhere. The fight is not over yet. Tom https://www.yahoo.com/now/cytodyn-files-protocol-u-fda-100000695.html |
"CytoDyn believes four weeks of leronlimab treatment to be sufficient to calm the cytokine storm..." Four weeks of storm? Hmmmmm... It is not easy to find CD12 Trial results published. Company website does not seem to help it's own case by much either... "Amongst all patients in mITT, the primary endpoint (all-cause mortality at Day 28) was not statistically significant. When age adjustment was conducted, the primary endpoint was much closer to statistically significant value." "With the age adjustment analysis in all other major secondary endpoints, there was consistent numerical superiority over the placebo group, with some secondary endpoints approaching statistical significance." Ok, enough of Coronavirus. |
I read the writeup on the CytoDyn website and Leronimab seems to have some efficacy against HIV and some cancers. The trial in the Philippines would seem to have little rationale other than the partial overlap in disease mechanisms among viral infections. In fact, there is an entire paragraph explaining CytoDyn's use of optimistic terminology in the writeup which reads as a statement saying "don't read more into the data than there really is". So, like glupson, I too hope that the drug is effective against COVID-19 but, thus far, there isn't much evidence that that is the case. |
Theaudiotweak, why do you assume the paranoid view? Maybe the truth is that this drug is not effective in severe covid, and the FDA would be doing the right thing based on real data not to grant it an EUA, much less a bona fide license. Seems to me like the sponsor is just grasping at straws, trying to find some use for this drug that was originally developed to treat HIV, and apparently didn’t make much of a mark in that area either. Their idea is only to make money. |
The real number was to be 4 doses specified by the drug maker not the 2 the FDA used for the Original Trial. Sure that would skew the final numbers. More disclosure to come out this week from the use of this drug on critical care patients in the Philippines including a former ex president. Not paranoid just alert and optimistic. Tom |
You are operating under a false assumption. The FDA doesn’t design the clinical trial. The sponsor is responsible for that. Then the sponsor submits the proposal to FDA for approval of the study plan before the trial can commence. In the phase 3 trial the dose and the number of doses and the amount of drug per dose would have already been established based on phase 1 and 2 results. The algorithm for making those decisions is also work done by sponsor, usually starting with animal studies before phase 1. Sounds to me like the sponsor simply wants to take another shot at showing an effect, using 4 doses instead of 2. If 2 doses was at least “safe” for the participants, FDA might allow it, but it requires a whole new proposal. And some new evidence to suggest 4 doses would be both safe and any better than 2. With a view to protecting the safety of participants, doesn’t that make sense? That’s the job of FDA. |
What's a recult? The drug has proven to be very safe thru all its uses and applications precovid. Most common complaint is skin sensitivity at the injection site. The trial on the former president of the Philippines these last days as reported by his son is said be a life saver and after one shot, 3 more to go. The limited doses for the trial may include only government and political figures for the rest of this week. That sucks if true. If that works then they may bring the drug in for the general public, we hope. Then onto Brazil which is in Dire Straits..and not the band. Tom |
theaudiotweak, "What's a recult?" Wrong finger on the wrong key. It was meant to be "results". lewm explained the process very nicely and simply. We all hope that everything is the way you already see it, but there is not much ground for that optimism right now. It may be that the drug is safe, as in not having very bad side effects, but efficacy seems to be missing at this point in time. Even the fact that the president of Phillipines "got better" after one dose means virtually nothing for anyone but him. There are many more factors that may be at play so holding onto this particular straw is not much more than desperate wishful thinking. Relax, let the things settle and run their course. The company is trying to make money off of something they invested time and effort in. It just happens that it has not made a splash in any application quite yet, and maybe never will. It happens daily. It may be more common than success stories. |
Just listened to a webcast by Dr. Bruce Patterson about covid 19 Long Haulers who may have multiple symptoms and who may need multiple drug therapies, no 2 patients being exactly the same. He is going to be setting up a website for long haulers testing and therapies with a 100 different doctors involved. Tom |
I first talked to Peter about 13 years ago. I would have thought he was about 35 and just starting out in business. All the enthusiasm and excitement in his voice. This a good man and is always willing to help, if he can even over the phone. Here's to the man getting better again. Make the good fight Peter!!!!! Ron |
