For my AV system I'm using two B&W 608 small subs along with B&W 603 S2 towers, B&W Center channel and B&W 607 surrounds to make a 5.2 AV system.
This is completely separate from my 2 channel music system.
This little 5.2 manages to seamlessly meet AV surround stage for the most demanding sound tracks. Point is 2 small subs are more than sufficient in a large room and easy to set up.