Computer updated and now Roon is blocked

If you right-click on the icon, what happens if you choose "open" or "Run as administrator"?

I'm using Bitdefender and it's been working up till the middle of week. I even turned off my VPN and tried, no love. Heck, I even turnoff Bitdefender thinking something in Bitdefender might be blocking it.

I've opened the program and tried to run it as both "open" and and as "run as administrator" No luck there either.

 Windows defender might be blocking it, see if it's turned off or if it's allowing Roon through the firewall.

Uninstall it, and then look under program files and under your documents.  Delete everything you find.

I would also try using a program called CCleaner, to wipe out any previous programs. 

If Windows upgraded, then there should be a restore point that you could revert the PC back to a point where Roon worked.

FWIW, I haven't had any issue with MS updates and Roon. I would look at the Windows firewall settings. Roon should be listed and you can see if it is allowed or not.

Bob