Hi OP,
Yep, turn the knobs all the way up on the amp unless needed for other reasons.
It may help you to understand that the gain of most preamps and amp electronics is fixed. The volume knobs only change the level of signal before or after the electronics.
For instance, with an amp, the typical gain is 26 dB (20 times the input voltage). The volume knob controls the V seen at the input of the amp, but the amp will still amplify 26 dB.
Preamps are often the same, with the volume knob coming after the gain stages.
Yes, less gain = less noise, but you aren't actually adjusting the gain in the devices, just the voltage levels coming in and out.
Clearly, the effective gain is changed, I'm only discussing the gain in the noise generating parts, which is the electronics.
Best,
E