As the one who explored extensively the "Pathi", or two Classic One units bridged, I assure you that the performance upgrade is substantial when using them mono. I'm guessing you have read my review of the twin units, or "Pathi" at Dagogo.com, but if not, enjoy!
Consider whether you are prepared for an entire tonality and frequency balance shift when moving to a different pre/amp or integrated. If you love the sound character of the One, but need more drive, then two units give that to you, and improvement in kind in other parameters overall.
You likely know the story. Imo, the choice should be whether you wish to open up the possibility of a major shift away from the tonality of the Pathos to something else. I found the Classic One series to have an uncharacteristically strong midrange, and it's quite beautiful. You would likely lose that in moving to a different brand. Something to consider.
Also, though it is a "do at your own risk" activity, you may wish to look into the Schroeder Method of Interconnect Placement.
There are several levels of improvement available to you if you go the second Pathos route. Frankly, I would look for a different source, or use the Oppo as a transport and get a fine DAC, rather than get rid of the Pathos. YMMV