Tube vs solid state (with all apologies)


So… I’ve been building guitar amps for a few years… and very familiar with tubes and circuitry…  and just entering the audiophile world. 
Is there a definitive opinion or discussion somewhere for help in determining where and or when to apply either?
smolder
There are pros and cons with each, and each situation is different, so there are no absolutes here. Obviously guitar amps and hifi amps are completely different animals with different objectives (a fact that should not to be overlooked), but for hifi use I just have not been able to replicate the sound I like with SS, so I go with tubes, and likely always will.

Not sure I’d be as picky about the sound of a guitar amp, but it’s understandable that folks who play want a certain sound. Always best to just go with what you like.
I once used an in for repair long time loaner VOX AC30 as the amp and speaker combo for my turntable with a Linn solid state RIAA amp. That rocked! 
All told, I guess I'm just a tube guy. I loved my genuine Pre-CBS Vibrolux dearly. With my Custom Shop "Pre-CBS" Fender Telly plugged into it, it gave me the finest twang in existence. It made my Les Paul roar. I sold the Vibrolux to a buddy who was more into playing than I was and replaced it with a tubed Carr Rambler, an amp that gives me a bit more flexibility than the Vibrolux did, but which still has 90% of the Vibrolux's tone. On the stereo side there were the Quicksilver Mono Amps, and now the PrimaLuna. It's not that I don't like trannies, it's just that I like what I got and I'm just not into shuffling stuff around any more.
Obvious that you're new here. There are more discussions on this subject than any other. Do some research on the forums. Just know that you'll come out of it more confused than you already may be.
When looking at guitar amplifiers, the entire goal here is creativity of sound texture. This is an artist area where the artist dials in and decides how the guitar is "supposed to sound". The circuits for guitar amps are radically different because they focus on how to "create a tone" based on the guitar string electro-magnetic pickups and adjustment dials available for the player. Things like tube signal sag, tube saturation distortion and coloration have a huge impact here. To this date, there is not a solid state device that can -exactly- reproduce the texture and coloration of tube distortation and saturation/breakup. There are some devices that can come close, such as Axe-FX hardware and many VST plugins available for audio DAW software.

On the other hand, home audio equipment is really focused on "reproducing the tone". Essentially, the "reproduction" of the signal exactly as it enters the preamp/amp. There are many opinions here. Some advocate a completely neutral/transparent reproduction with no coloration at all. Others prefer some sort of coloration that could be represented as a lush or warm or smoothed type of sound. These are very subtle effects, but they can mean a world of difference to the audiophile listener. Even there there is this slight "coloration" to the tone, it is NOWHERE near as drastic or extreme as you will find in guitar amps.
unleash the tornado….

but a great designer with ears and taste can extract awesome sound out of either tubes or Ss or a hybrid…. just like a great guitar player….

now, where did i put that fret less bass… ?
As a guitar player myself, you are basically asking should I use coated or uncoated strings…or a Marshall vs.Fender. Lots of opinions and reasons for either one. You will also get lots of opinions on this question. However, I will jump in and say a lot of folks go with tubes for the pre-amp, SS for the amp. You get most of the tube sound with more power and much less heat, and normally less cost.
For me, I went with an integrated SS class A amp to avoid the minor hassle of tubes, but I get very close to the tube sound. 
For my guitar I use a fender tube, tried the digital versions and never warmed up to the sound. 
Hope this help a bit.