If you listen carefully to the cymbals, you may notice a reduction in volume after 30-40 plays. After 100, it's definitely noticeable.
Mishandling, a cheap conical, or a worn stylus will increase both high frequency fading and ticks. Play the whole side - don't drop or pickup the needle in the middle. And never leave records out to gather dust. Don't touch the grooves, either.
If you do all that, the need for cleaning will be reduced, but there's no substitute for a good washing if you've played it a lot.