@sparkymaui The weak spot in the ST-70 design is that they really needed dual rectifiers. So if you play the amp at higher power levels the rectifier tube is the most likely tube to fail. When it does so it will likely also blow the main fuse.
The main concern here is that your filter capacitors are new. ST-70s go back a long way- if you have an older one and the filter caps in the power supply have not been replaced, I would not run the amp until this is done, as bad filter caps have a way of damaging power transformers!
But if the caps are OK, then the rectifier tube itself is the most likely fault.