I would decide on speakers first.
I had a living room approx. that size (16' ceiling) in the late 70's and was never satisfied with the sound of my small (Rogers/Braun) speakers - even in the near-field.
I didn't have subs, but did have the add-on AB1 woofers for the Rogers.
I'm guessing the problem was the high ceiling as they worked OK in other large rooms with 8' ceilings.
Anyway, if you have the original Sprout there is the later Sprout100, plus NAD makes a few small case integrated's with BT/DAC and all that stuff ($1500-$2500, or around that new).
We now have 2 CD based mini systems (computer room and living room kitchen area) that are used for your intended purpose - so can relate.
The new spare bed/computer room setup has been getting quite a workout.
DeKay