I use Roon DSP to tweak my sound in several rooms with acoustics ranging from not bad to problematic.
Turns out my toughest room is the family room that is open into the kitchen and the rest of the first floor. I’ve tried many gear combos over the years all not fully up to snuff. Currently run Bel Canto c5i to Sonus Faber Concerto Domus. Not bad, but I apply a convolution filter I created for room correction then an additional 5 eq corrections to get things just right. 3 deal with highest and lowest frequency adjustments. Then I like a touch of ‘pierce’ boost 4-6 kHz. Then a speaker adjustment for timing since I do not normally sit dead center. That does it!
So depending on need, assuming a single filter counts as 1 tweak, I do as many as needed. Have yet to not apply any.
Same for headphones. The canned convolution filters for each apply multiple filters in combo as well.
All in Roon DSP if you want to call that a single tweak. 😉