Multicell horns are used to reduce the level of early reflections in the listening space via tight control of their dispersion pattern. Most famously, the Altec 203B 'Long Throw' 2-Cell with a 20x40 degree pattern was 6dB hotter at 100 ft than other multicell with a 40X100 pattern. They had unmatched reach and clarity before distributed delay systems, but the same goal: improve the direct to reflected sound balance for improved speech intelligibility. What audiophiles call 'detail'. Same goal in the studio: more direct, less reverberant field. As for listening fatigue, sorting out the direct sound from the reverberant field would seem to be far more strenuous than listening in stereo. Suggest reading "The Language Game" by Christiansen And Chater, C. 2022 for a good description of how the brain parses the sound field for language purposes.