What type of speaker would sound better?

3 way 2 way allways have a midrange hole 
what would sound best is the 3 way of the vintage allison AL130 w/ the unique proprietary and inovative  sealed cabinet dual 8" push pull woofers and the CONVEX cones of the tweeter and midrange  nothing since is as inovative and amazing 50+ years old tech not surpassed 
Roy Allison was amazing ! 

My all allison 11.2 HT  is pure sweetness ! total envelopment ! has taken a bit of time to find all the speakers!  

2 way allways have a midrange hole 

Not the case.  Some speakers with a very large woofer mated to a tweeter that doesn’t play low perhaps, but most 5-8" woofers can mate seamlessly with many tweeters.  Their downside would be tend to be limited of deep bass output, not a midrange hole.

@gdaddy1 

+1 I have used your automotive manufacturing analogy many times to debunk the need for a Speaker to cost $100K+ (or $50K for that matter!!). Speakers just aren’t that complex and science on good sound is pretty much decided outside of driver technology and exotic cabinet materials. None of which cost anywhere near as much to design and manufacture as an automobile, even a crappy car! 
 

To the OP’s question, do a deep dive into either the 2 way or the 3 way and see how the thing is built. What separates a good speaker from a great speaker is the driver technology (think ScanSpeak, SB Acoustics Satori, Purifi), and cabinet construction. Cabinet bracing is SOOOO important and the brands that cheap out on it are putting one over on you (Klipsch, Tekton, Zu Audio, etc.). People like to talk down about B&W and Wilson because the voicing is a little hot, but their cabinet technology and drives are top notch! If the 2 way has better drivers and cabinet than the 3 way, it has a strong chance of sounding better. 

Sadly or maybe not so sadly, there is no magic formula for what is going to sound best. The room itself, its size and shape, listening position, acoustic treatments, type of music and whether or not you intend to augment low frequency response with subwoofers or not all play into what will work the best for you. In general, the larger the room the more low frequency cone area you need to have for full bandwidth response. The louder you want to listen, the more low frequency cone area you want in general. In your room I would want something with a couple of 12" drivers for low frequency support so that almost certainly means at least a 3 way system if not 4 way. A pair of Legacy Focus SE for mains would likely work very well in your room. Not cheap but this is a full bandwidth solution with a very healthy dynamic range and by some reviewers among the very best available at any price. Worthy contender at the very least. 

There is also the one driver option.  Can be magical when done correctly!