To get my system set up, I first hooked up a monitor/keyboard/mouse to my Serener. It can hook to those devices, its just that normally I don't have it hooked up. In that configuration, its just like a normal desktop (except size wise). It has a USB out and LAN connection, so... I loaded it with iTunes, slimserver, connected my Waveterminal U24 (USB on one side, coax digital on the other), hooked it to the network. I took the digital out from the Waveterminal and ran that to my DAC...
The Serener I have runs Windows XP, so it recognized the USB device and installed the drivers. I already had my library ripped to a network drive, so I gave the Serener password access to the network drive, had iTunes scan it and catalog it, and I was done...
WinXP has the whole remote desktop thing built in. I think I may have had to enable the computer for remote access, but it wasn't hard. I think you may even be able to use a windows mobile device to run a remote desktop off a network computer. My airpanel actually communicates via Wi-Fi, so I had to have an access point somewhere on my network. Not too hard...