I’ve owned Duos for a long time (with the 225 sub). The trick in my estimation is to get the sub to cohere with the midhorn; that often leaves you with a somewhat bass shy performance. Push the integrated woofers harder and they sound discontinuous. I know Jim Smith has a world of experience in setting these up. I cheated and tuned the integrated woofers as described above, and added a pair of 15" subwoofers and DSP controller for those. The result was more natural transition between the mid to upper bass region, with more grunt and foundation on the bottom.
In terms of power cords, I had a few audiophile brands and eventually bought Kubala-Sosna for the entire system. I only changed out one cable- an interconnect- to a higher grade in their line.
With the integrated sub I did hear a difference, not as profound as with amps (Lamm ML2) or line stage or phono stage.
With the add-on subs, I didn’t bother with any fancy power cable. I roll them off at 55hz. Combined with a change in phono cartridge, from the Airtight line to stone Koetsus, I have a much more dramatic presentation that I find pleasing, listening to a lot of small combo jazz, some rock, and a bit of everything else. Jim would probably tell you placement is more important than the power cord, but the trick with the Duo is that you are pretty much stuck with a position for the whole speaker, not just the integrated woofer. There was a third party stand made by Mapleshade to set up the horns separate from the woofer, but very few units of those were made to my knowledge. I’ve seen them for sale only occasionally here.
Good luck- if you experiment with placement, settings and the like, you can get that speaker to sing, but I think a lot has to do with the associated equipment as well. They can be ruthless in revealing what the upstream components are doing (or not doing well).