I use four 10" diameter subs in my system.
Depending on which speakers I'm using, my midwoofers range from 10" to 15" in diameter.
In general, subwoofer drivers are optimized for subwoofer frequencies, and midbass drivers are optimized for midbass frequencies. While in many cases each "can do" the other's job, imo that's probably not going to be optimum.
Duke
dealer/manufacturer