Cable management....crossing at right angles or

A rats nest of wires with no discernible pattern. 

Rat's nests are very underrated/under appreciated. They serve a vital purpose.

All the best,
Nonoise

Randy @randu 

Try these, I found them to be quite effective in isolating IC from PC cables. 
https://shunyata.com/products/accessories/df-mini-cable-elevator/

You are worrying too much about this! there is a difference between being neat and being obsessive for no reason, unless of course you are having a problem that you have not mentioned. Take the lid of your pre-amplifire and look inside for some aspiration. There are a number of steps you can take to untangle the mess but I think you already know what to do!

If you are using good shielded power and speaker cables, it is unlikely you’ll hear a difference no matter what you do.  If you are using stock power cords and and zip cords as speaker wires, that’s another story.

All the best.

@ghdprentice 

I do know it is low on the totem pole of audio tweaks, but my anal personality can't just forget about it. Every time I sit down to listen, I know it is lurking in the background. I can almost hear it snickering at me during the quieter moments.