Probably.
The reason I have never done it is because I always buy the very best of something I can possibly afford... like an amp... so I would be buying two amps and investing 1/2. That from a quality of sound would be a huge step down. Hence. I could never do it.
Second, I am always concerned with character of sound. So, I would have to use two amps of exactly the same design. Either exactly the same amp or like a Pass X150.8 for the tweeter and a Pass x350.8 for the woofers.
None of this kind of stuff made any sense to me without a nearly infinite budget.