I have the Aurender's USB connected to my RME DAC which I use in a headphone set up. The RME doesn't care about the source clock, it uses it's internal clock for all inputs
Keep in mind thats just a USB 2.0 cable, nothing special. I think my Lab 12 does sound better via coax, I haven't A/B 'd the two extensively, could sound better with a purpose designed USB audio cable , not sure. Like everything, it's all subjective
I'm holding off on any further cable purchases until I get my new pre. I just picked up some DH Lab Air Matrix Cryo RCA and they are super high quality . I will eventually pick up the DH Labs USB and revisit .