I've owned the Innuos Zenith Mk 3 and currently own an Antipodes K50 G4, so I definitely agree with verdantaudio comments on player software of choice. The Innuos Sense software is fantastic, I actually like the search capabilities much better than Roon. The other point to consider is that the Pulsar does not have internal storage whereas the K22 can have up to an 8TB internal SSD that's easily user installable. From my personal experience, music stored locally on my Zenith sounded better than either streamed music or files stored on a NAS. I would same the same applies for my K50.
mclinnguy - I run my K50 using the playback method of Squeeze with Roon Server. This seems to give the best overall UI and sound (to my ears).
Finally, a couple years ago I had a Bricasti M1 SE DAC with the network card, and it sounded really good when connected via network to my Innuos.