How big a room, how loud do you intend to play the system and what are your other components? It is a bit hard to gauge what the basic requirements of the speakers you need. What are you currently using and in what way to you hope to improve on the sound?
I have heard some fairly small speakers sound superb in very large rooms. For example a two-way YG Carmel speaker did not have any problems handling a ballroom in a mansion that was at least 25' x 50' x 12'. But, then again, if you require rock concert level, it would not work. It would help to know what you have actually heard, and what you liked and did not like and the particular settings for what you heard (in a comparable room to yours?).
For the Nenuphar Basis speaker I mentioned above, the room was a fairly large conference room, close to 25' x 50' x 12', and the speakers were well out into the room and bass was surprisingly strong, with no need at all for subwoofers. This is what a very good two-way system can deliver. The Fyne system I mentioned was playing in a very small room, so I don't know how they would sound in a larger room, but, I think they would be a candidate.
