Except in the unlikely event that the two cartridges need the same VTF, antiskate and arm height settings, those will have to be adusted with each cartridge change.
Additionally, much depends on how accurately the headshell/tonearm connection was machined. If it puts the cartridge in *exactly* the same position each time its removed and replaced, great. Of course no mechnical interface is perfect. To whatever degree there's room for variation, you would need to re-check overhang, zenith angle and azimuth.