@jrcotner Interesting and very astute question! Many audiophiles often ignore the very important issue of component synthesis, which often makes a world of difference. If your intention is to drop 10K in one place, I would recommend spending a few bucks in travel expenses for some serious critical listening in one or more high-end shops. With proper advance preparation and communication with the appropriate shops and a 10K budget you should be able to score a serious discount(s) on some very nice equipment.
That being said, based upon personal experience, I can attest to the fact that McIntosh amplifiers ... well ... McIntosh amplifiers sound stupendous with just about any appropriately matched speakers. However, my ears particularly enjoyed Sonus Faber matching, which is probably why McIntosh Group acquired them. After the better part of a 9-month serious seat-time speaker upgrade quest involving, as best I can recall, somewhere in the vicinity of 18 different speakers, I eventually came home with a pair of Revel that sound great with my MAC. The MAC sounded great with a pair of Paradigm I previously owned, as well, but the Revel were/are a step above.
As for other amp/speaker marriages that I've spent serious seat-time with, in your target budget, my ears particularly enjoyed appropriately matched Luxman & Revel; Luxman & Focal and Simaudio Moon & Martin Logan.
Generally speaking, with efficient or sensitive speakers, you won't need massive amounts of amp power for a 15' X 15" sound room, especially if you listen at modest or less than live performance decibel levels.
Good luck in your quest.