My room is approximately 20 ft x 35 ft. I'm using two REL S/510 in a stereo pair. Using speaker level connections for two channel. I have the gain and crossover set really low. They blend well with my full range speakers.
If I turn them up very high, it's too much. I can't feature needing bigger subs for two channel, but I haven't heard them.
They don't have enough oomph for home theatre. I have a larger SVS sub that kicks in when I'm watching movies