You'll probably have to get the sub signal from the speaker leads, so just about anything will work.
Plug the ports and try to keep the sub crossover high, 60-80Hz.
I find with subs that an EQ is almost 100% needed to clip peaks, so if you can find a sub with built in DSP that's a big plus.
Check out the AM Acoustics room mode simulator to help you place it and the speakers.