I have run Dynaudios with my Bel Canto Ref1000 mk2 and they sound good, but now I have Von Schweikert VR4SR mark 2 and boy does this sound nice. Mids to die for. My Pass XP10 and Bel Canto DAC3 help smooth things out too so I don't know how much I can simply credit the amps. I think like any components, you can't generalize about synergy. I do agree with Semi as well that you probably want a speaker on the warmer end of things, and then the Class D high damping factor helps control the bass of those speakers well.....
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