My room is 26' long and 16' wide. I have my speakers 70" into the room (measured to the back of the speaker), and about 7' 9" apart (measured center to center). I sit about 9.5 ft. away from them. To my ears, this is magic in my room.
Your biggst issue is going to be moving the speakers around until you get the smoothest tonal balance, exciting as few room modes as possible. But be sure as you are moving them around, you don't forget to move your listening chair as well. Experiment with moving speakers/chair at different distances, and not always exactly the same. Contrary to what most believe, this could take months to get right, but be patient. Your room is a good size and has good dimensions. If you have the luxury of placing you and the speakers wherever you like (i.e. a dedicated room), you should eventually end up with a sound you like. That is, if the speakers you have are really the ones you want.
Oz