Sound System on $10K Budget

All, sorry if this has been asked a million times before. I am looking to build a home audio system from scratch and want to keep it under $10K. I have no idea where to start, and scrolling through this forum has just made me more overwhelmed. For context, I have a headphone setup (Meze Empyrean and HD 800S and a Vioelectric V280/1). Unfortunately, I haven't used the system in over a year--I find it too difficult given all the wires, turning my desktop on, etc. As such, I am looking to put in a home audio system that I can more casually listen to as I work, cook, etc.

The room I am putting the system in is 34 x 20 with 12 foot ceilings. I am looking for a system that is just all around good (jack of all trades master of none) given the budget. I will not be doing any room treatments, etc (not worth the marginal benefit and I am not looking for perfection here). The system will be used daily for TV and for music. As far as genres, I really like everything, but skew towards alternative/indie/pop/rock. I am guessing I will want a sub, but I have no idea and am flexible. I was thinking two loudspeakers, but I am flexible.

FWIW, I don't really believe in expensive cables and think it is a waste of the budget at this price point, but I am open to other opinions. I am open to buying used equipment (I actually prefer used equipment--I believe quality audio equipment should last forever). Overall goal is simplicity + all around good.