My opinion:
- Make sure your ground is in good working order.
- Run a sub panel from your main panel. This will give you big thick wires and minimal voltage drop due to load.
- Use a voltage regulator in your audio room. This will minimize the effects of the outside voltages swinging due to power company fluctuations as well as other household loads like the oven, AC, etc. and it will add some amount of inherent noise blocking due to inductance of the autoformer.
- Use RF/EMI blocking conditioners for all of your sources. Furman with LiFT/SMP or Zerosurge, all have excellent low frequency (relative) noise filtering.
I say this not just from listening, but from watching my home VAC swing no matter where I live. By far the largest measurable improvements have come from the voltage regulator.