Power isolator versus need for a better Power supply

simple answer: no. The wall wart creates its own noise. BTW it creates noise for what it powers and also feeds some noise back into your other stuff, since its on the "clean" side of your isolator.

Hello,

If you can get some linear power supplies for each you will be good. Besides not creating noise they have continuous clean power. 
An example is if you unplug your wall wart your switch or Nucleus go dead instantly. If you plug them into an SBooster and you unplug it from the wall there is about 15 seconds of power left in the caps. In the end you always have clean constant volts going into your device which really helps with consistent sound and preventing noise. 
Two of these are about $800-$900. Then I would at least change your wall outlet to a hospital grade. Besides better material you get a much tighter fit when plugging you Transparent into it. Basically what Mike was talking about above. So for less than $1000 you can make a big difference. 
If you cannot upgrade your Grounding and power system from the outside in the check o

Out Puritan products like the PSM 156 and the GroundMaster City. It will really impress you. Really great if you are in an environment that doesn’t allow you to rewire your power. You can isolate you from all of your neighbors and even yourself like from your DVR or refrigerator. I hope this helps. 

The biggest improvement I can make right now is to find a refrigerator with less compressor noise.  I actually turned down the freezer temp setting and found that the compressor was cycling on and off quite a bit less.  Freezer is now 0 to 5° which is fine.  

If you have a good “power isolator,” whatever that is, not sure the refrigerator should make much difference.  What power conditioner are you using BTW?