I have a MX121 but plan on changing to a MX123 soon. My theater is being rebuilt in a new home. I would test the cables. You state that there is a signal; however, have you tested the outputs of the amp powering the center channel? Swap amps and run the center signal to the swapped amp. Also test the center channel speaker with another amp that has a good signal and is outputting a signal that is either left, right, rear, or anything not center. This will help to let you know the center speaker is functioning. This would be my first test and then swap amps to the center and or cables from the pre out on the MX121 with another set.
If the source on the MX121 is HDMI and not all analog, you may want to check the settings to see if you need to change to analog outs for the audio out related to the source feed. I purchased a 5.1 HDMI splitter that allowed me to use RCA analog outs. This may allow you to convert the source signal (blu ray, DVD, etc.) to analog which then can be plugged into the analog in on the MX121. This will only work for one source unless you get a rocket fish HDMI source selector. This will allow you choose up to 4 sources and then run the audio to the MX121. The HDMI splitter has a HDMI pass through which enables the video signal to be passed to the MX121 source inputs. I always used media player as my default source. Don’t forgot to check audio signal setting such as PCM, pure direct, stereo, etc. for the selected source on the MX121.