Depends on how critical of a listener you are. I was in the same boat- loved the sound of the LS50s but even with subs and in my medium room they didn’t sound big enough.
I have upgraded several times since the originals and listened to all of the recent R series and REF series including Meta.
KEF has altered the voicing of the newer speakers including the LS50 meta to a point where I feel they ruined the sound of the original LS50s, a very special sound that is basically the only KEF speaker I like. The newer models sound too rolled off and bland to my ears, they veil the midrange. Also many can sound metallic with the wrong amplification.
My recommendation to you would be the Andrew Jones designed MoFi Sourcepoint 10 which are much more efficient, have a huge sound and perfect for your room.
I listened to these for quite a while at the last AXPONA audio show and they were a favorite. Crushing deep bass from the 10 inch woofers, clear neutral midrange and treble. Highly recommended.