I2S, PLL and USB

Groovy, ill give it a go

I2S is concetually good and many swear by it but implementation is sketchy and your example is just one of many.  

I'm with Erik on USB.  Try both and if you can, and see if you can tell the difference?  Unless I2S sounds better then USB should be your go to.  Lots more cables availabe.

For digital signals I always like silver plated (or solid silver) cables and Audioquest offers lots of them in any price range.

Jerry

I just got the components to try it. Was just looking for insight or obvious gotchas between the 2

I'm a big fan of USB, but your ears and convenience should tell you what to do.

What's most convenient, and what is good sounding to you?

It's not like your choice of USB vs. I2S is going to alter your eletric bill. :)