Our only reference for timbre is acoustic instruments played without sound reinforcement. The recording process alters it as do the playback instruments/components. Also we have so many non acoustic instruments, we have no reference for timbre with this. If this true how can stress be caused by imperfect timbre.
Levels of ASC in any particular individual cannot be known by any of us. Many report very high levels of musical engagement with very ordinary equipment. It would seem logical to suggest those who seek and need highest quality audio components are more resistive to high levels of ASC. On the other hand, considering there are differing levels of ASC, perhaps those with the greatest needs equipment wise wish to have even higher levels of ASC than previously experienced. In this case audiophilia is an affliction in which, just like other addictive drugs, tolerance may be reached which means even greater amounts/better equipment needed to maintain the high.
Now, the above contingent on what are the goals for any particular audiophile, perhaps the equipment itself brings about certain levels of ASC. No doubt humans can lust after material objects, think about how many humanize these objects, men often give their cars women's names. My neighbor has males names for my cars.