BW 801 D4 or BW 802 D4 + 2 subs

I would always pick the alternative that goes with subs. There are many good reasons, but one of the main one's is the ability to put an EQ in line with the subs.  That plus a high pass filter will almost always give you the chance to get better overall bass response in a room than trying to get the same from just two large main speakers.

Then there's a litany of other benefits, like increased dynamic range, lower main amp stress... etc.

I recommend the use of the AM Acoustics room mode simulator to help you place your speakers and listening location, careful measurements and GIK soffit traps in the corners if needed.  If you do all this well you are going to have a very difficult time finding a system that performs better in bass speed, impact or system dynamic range and clarity.

@rick_n 
i´m building the house. will think about treatment later

The room is 7meters x 12 meters  (3.5meters high)

the speakers will be placed on the 7mts wall
there will be a fire place between the speakers.

floors will be porcelain tile, with mat close to speakers.

@erik_squires 

do you like these subs?  (not sure about the s510 ou s812)

or recommend other brand?

about 5-6k to spend on subs.

With a fireplace between the speakers and porcelain tile floors  it's good that you're going to think about acoustic treatment. You're gonna need it.

That's a really large space that you need to fill and pressurize.  Couple of thoughts beyond the good thoughts from @erik_squires and @tomcarr 

1-Going with the Main + Sub combo will give you options to move the subs around the room and tune the bass.  If you love the sound of the Mac integrated this is probably the way to go

2-The larger B&Ws will push the limit of the integrated without subs.  You may need more power to keep the bass clean esp. at louder SPLs.

3-If you really like a full bottom end and a properly pressurized room the RELs might get you there or they might not.  You may want to consider the JL Audio Fathom line of subs.  They have 2x the power and more usable output then the RELs.  They are known like the RELs to be very musical and two channel friendly.

4-If the porcelain floor remains mostly uncovered the lively top end of the B&Ws will become even more so.  Will you be happy with that sound? Good luck and cheers.