Best Audiophile desktop for under $2500?

Using a computer in an audio system can be as good as anything else mentioned here. You just need to do it correctly.

I posted earlier about my $5k fan less PC. I run 6 monitors of it and it is a powerhouse machine. It does not make a peep of noise. However, that is not how I setup my streaming, I use a $500 DELL machine that is the size of my hand. I have it kept under a bed in the adjoining bedroom to my office. I have perfect streaming throughout the house from this little machine running ROON Core. 

Fibre cable (glass) is your friend in this scenario. My setup needs a bit of computer savvy to get setup and keep running. Send me DM if you want to discuss.

I have worked as an audio engineer, and currently I do high end workstation builds.  I would be more than happy to provide you with a parts list and help you find a reputable builder in your area.

Here's a link to a parts list that I put together as a starting point, I'd be happy to go over the parts selection and reasoning behind the choices.   https://pcpartpicker.com/list/spgmJy

@deanshias I use the Matrix Audio Element H USB 3.0 on an ASUS Z690 motherboard. I was shocked at how big a difference it made (the rest of system is Cambridge Audio DACMagic 200, Audioengine A5+ speakers, and Senheiser HD599)

I use AVADirect who offer silent PCs as one of their build options

Silent PCs, Quiet Computers, Custom Silent Desktops | AVADirect

Those aren’t anymore silent than what I suggested. I would be interested in seeing a detailed parts list for one though.

<edit> I just found one and I’m not terribly impressed with the components they are using so far.  Changing the configuration to match it just costs $1100.00 more.  </edit>