I would generally agree with a good number of the responses that indicate a "great deal of added expense to do it right" but yet the benefits are there if there is cost no object.
But here in "beerville", after experimenting with multiple different jumper wires between my mids and highs of Aerial 10 Mk II, I did find one that I liked substantially (Signature series, AntiCable).
Then at the suggestion of long time friend/audiophile Duane, I tried some Mosaic advanced tech speaker cables (now defunct) in a bi.wire mode .. UnBeLieVabLe the difference!
If you want similar tech .. Bionic Cables are similar yet better. I am using their entry level RCA, it is also amazing (coming from much a-b'ing on my system)