2nd system for office, all-in-one integrated suggestions

PS Audio bundles the Sprout 100 integrated with Elac 2.0 speakers on their website:

https://www.psaudio.com/products/sprout100-integrated-amplifier#shopify-section-template--20408817418530__0e8d8927-480a-4c8d-8a92-e46aa185d647

I've never heard one, so can't comment on that; but this one has many of the features you're looking for a very reasonable price. 

Build around Vanatoo active speakers is an option to consider. 

Thanks for all the input...I'm leaning toward building around the PS Audio Stellar line, but I'll check out all of your suggestions, really appreciate the time!

Considering the speakers, you are not in the esoteric price range. Not trashing them as I am really amazed at their price point.  ( I have D5.1's in my shop powered by a V3)  Really, don't know how they do it. 

So the amp is not that critical. Look for a solution with the best internal DAC  and streaming software. Unfortunately some very nice integrated amps have $5 DACs in them.   Even the Moon internal DAC I would not write home about.  To go external DAC and maybe IOTA integrated?  If going to better speakers, the Hegel, Atoll, AudioLabs integrated are all exceptional.  I put them a notch over Rega, Naim, Linn, Cambridge, Marantz etc.  Ones I have heard. I have not heard a PS since the first generation when I lived in Boulder.  PS does seem to make some very good electronics, but I just get a bade taste with the snake oil they also push. 

My desk is a PC as server and streamer.  I run JDS Atom+ DAC and  preamp/phones into a Schiit REKER driving my Vifa/Dayton 4 inch mains and an 8 inch sub. Once I tuned enough JRiver parameters, I have eliminated the vocal sibilance I am so sensitive too.  It plays more than loud enough with all of 2 Watts.  I tried my ELAC's on it and sorry, as good as they are, they were no match for the Vifa XT-25 tweeters. Electronics under $350!  I really want to hear an Aries II in the system.   Now, I only listen to headphones occasionally at night. That is not my primary listening, but the $109 JDS seems fine.  I also have an Asgard. Can't tell the difference. 

If I were buying a desktop from scratch, I might start with Sonas Faber Lumina IIs, go for the bigger 12W Schiit amp, Probably a JDS Element DAC, maybe WiiM streamer.  All that way less than the above mentioned prestige brands and I would match the sound any day. Maybe the RME DAC instead of the JDS. Not sure it is smoother sounding, but the feature set is worth the price. 

I've  had a PS Audio Strata for a few years now and I keep going back to it.  My other system has a tubed front end and vinnie rossi amp.  The Vinnie system has a little more bloom and body but I've also spent more time, money and tinkering to dial it in than I have the PS Audio.  The PS Audio has been great for me and the only thing it doesn't have is the phono stage built in.  Streaming is very easy as I use airplay from my phone, bypassing the use of the PS Audio app completely.  The PS Audio has channel balance and gain control per input which I do find useful.  Another example, I swapped out the PS Audio for a Rogue Pharoah on a pair of Magnepan .7's.  The PS Audio had more top end and better bass.  The Rogue had a little extra depth/dimension.  The PS Audio has been dead quiet for me.  I also hear the differences in cables with the PS Audio.  TMR Audio had a couple very reasonably priced.