Plenty of very nice modern 300B, 845, EL34 tubes. I'd definitely have an issue devoid NOS for most others.
Would you buy a tube amp if you were unable to use vintage tubes in it ?
Not available or too expensive.
Hmm.., I don't think I have a definitive answer for myself, but I would do my best to avoid such amps. There is no substitute for great tubes, I guess, especially if you value sophisticated sound.