What process did you use to integrate multiple subwoofers for 2 channel listening?

Today I will be trying to integrate up to three subs. Two are matching Rythmiks F12SE, and one is a REL R-328. The Rythmiks have a variety of adjustable parameters, including phase, crossover, and gain. There are other switches and passes on the sub, but I'm going to try to keep it basic to begin with. The REL has variable gain and crossover; the phase on REL is either 0 or 180.

I have REW for measurement. I will be buying a few more furniture sliders this morning, on doctors orders. ;-)

QUESTION: If you have multiple subs, by what process did you integrate your subs? One at a time? More? Which adjustments did you try first and in what kinds of increment?

I know that trial, error, measuring, and listening will all take time. Rather than look for a needle in a haystack, I'm curious what sequence or process was most effective for you.

Thank you.