USB cable: One Continuous length for Best SQ?

Relative digital newbie here.....In audiophile, digital music applications, does it matter if one splits up a long run of USB 2 connection between computer and DAC into separate attic/wall space lengths and shorter lengths which would connect to wall USB outlets?  Ideally, I’d like to connect my Mac (in a bedroom) to a DAC (connected to the living room audio system....looking at possibly a Schiit Bifrost 2 or similar price range).  I’m assuming this would require the use of step up devices along the path as I’m allowing for between 50-60’ cable between computer and DAC?  Would this impact sound quality?   Currently using my Mac > aging Airport Express in conjunction w/iTunes and the “Remote” app & no external DAC....Not interested in going with a different wireless streamer setup at this point.  Thanks!