I will answer your question with some dialog from the classic scene in Katz's deli from When Harry Met Sally. "Yes, Yes, Yes!!!"
Just the Native X feature alone is worth the upgrade. Enabling NativeX (from Native, which is the best mode on the MK1, takes a digital signal which is a bit congealed and opens it up to allow each instrument to exist in it's own acoustic space. It may be considered on the subtle side at first, but as your ears become educated to how digital sounds with such low jitter, (under 1 picosend I believe) the effects is not subtle. Even standard redbook audio takes on the quality of hi res material. It's pretty amazing. As HIfiAl states the benefit may depend on your system. My monitors may have a "tad" more resolution than yours, so who knows.
I am using it with the bridge, not the other inputs. I can't imagine how the MKIII could be improved other than support for DSD.