Yes it is possible but careful volume matching, phasing, and cancellation issues must be addressed. I am currently using five subs(3 different mfr's) in my main HT/music system and believe me, it takes some work and patience to get it "right". I am using a pair of Klipsch RT-10d's in the front corners, a Klipsch RSW-10d next to my recliner, and SVS SB13+ next to my sofa, and also a Revel B15. Different driver sizes(10"-13"-15"), amp powers(500w, 700w, 1000w, 1000w). And yes, my bride is a keeper.
Bill