In the last months, I have been comparing apples and oranges - a small OTL amp on headphones and desktop speakers, and my main Krell/Dynaudio Consequence system. So this is really "micro" versus "macro". I use a Korg MR-1 recorder to record LPs on the main system, and playback on the small system, so the nice thing about this testing is that the source is pretty much the same.
Experience? Of course the big system beats the small, in most ways (as it should costing x times more). Music becomes "embodied" in a way the small system cant deliver. At the same time, there is green grass on both sides of the fence, and one should learn to recognize and care about the good points of a system, not listen for what is bad.
In my case, the OTL (Audiotailor Jade) delivers top clarity and a good soundscape that is more neutral than e g my Ming Da tube amp (18 watt single-ended triode) but then, the playing level is different, this is a micro system. OTL in big watt amps may be difficult, or not really the area where this technology shines, I dont know. OTL seems theoretically better, but it has to contribute in a larger context and drive the speakers right.
I have heard a very good OTL system of an audio friend, but it still had a little bit "look in here" quality compared to my own system that "pushes" the listener more. My metaphor after listening to that system was Jewel shrine. I find some of this quality in the Jade too. OTL can sound a bit thin or hollow or cold, but this is much a question of speaker match (no thinness with Jade driving Senn 600 headphones), good tubes, etc. But from my limited experience, SET amps outperform push-pull OTL's (and standard p-pull) especially in the "human" mid-frequency region like reproducing voices.
I am no engineer, possibly, "hybrid" is a way to look, based on this discussion. Musical Fidelity offers a s-state add-on for tube amps that got a good review in Stereophile if i remember right, although adding amps may not be the best thing according to straight wire with gain philosophy.
If someone announced a SET OTL amp 300 watt+, and it got good reviews, I would certainly have liked to try, and might buy it. Today, my speakers thrive with 2x600 watts and my feeling is that they would sound even better with 2x900 (or, two Krell 600s). I think tube amps often have stronger watts, as a rule of thumb, so perhaps 300-400 would do. But then we are looking at extremely expensive niche products.
A question is, if this is due to taking a technology out of its "easy" terrain. Solid-state + big watts= quite easy. Tube Set and Otl low watt - easy. Each of these, to middle-low watt - quite easy, like 20 w triode. Combined not so easy. Higher wattage - very difficult. Correct?