Simguy the best practice would be to replace one Orange fuse with a Purple fuse one fuse change at a time starting in the same direction. If the new Purple fuse immediately sounds better in most ways over Orange in the same orientation, then simply go to the next fuse location, no need to listen in both directions. If however you encounter one application or two where a Purple fuse does not immediately sound better in most ways simply reverse direction. Again you don’t need to listen both ways with all fuses, only when a single Purple fuse is not a significant upgrade in most ways over an outgoing Orange fuse. This is down to a new long duration high-voltage conditioning process first developed for SRX cables.
I hope this helps.