The Ayre DX-5 is a re-badged Oppo player that uses the stock Oppo DSP/HDMI/digital. However, the Ayre only has stereo analog outputs.
The stock Oppo DSP configuration for speaker size/distance/level really only applies if it had 5.1 analog outputs. As far as I know, these settings do not affect anything going over HDMI (i.e. 7.1 LPCM over HDMI).
So I would use the speaker size/distance/level settings in the Bryston. If you are playing stereo music, none of this makes any difference anyways.
The stock Oppo DSP configuration for speaker size/distance/level really only applies if it had 5.1 analog outputs. As far as I know, these settings do not affect anything going over HDMI (i.e. 7.1 LPCM over HDMI).
So I would use the speaker size/distance/level settings in the Bryston. If you are playing stereo music, none of this makes any difference anyways.