One possibility is that, because you haven’t done any PEQ, some frequencies are being reproduced at the (mostly) correct SPL while others are too loud and overwhelming. The e110 doesn’t have any PEQ functionality built-in so you’d need to add an outboard PEQ device.Good advice.
Also, in order to optimize the subwoofer integration, you should be connecting your pre-amp to the e110 inputs, and the e110 outputs to your speaker amp, which is then connected to the speakers. This ensures the e110’s crossover is applied.There is no crossover in the e110, so there's really no point to doing this.
Turn the FEQ, all the way down, Counter Clock Wise.What's an FEQ?
My suggestions are to consider a preamp with bass management, an external crossover and/or an external DSP for equalizing the sub in your room.