Yes… an Aurender N10 will make a profound improvement in sound quality. I own two Aurender and auditioned the N10. These are audiophile components and perform at that level.
Optical connection would be the least preferred. Coax input to the Mac would probably sound the best. USB can sound better… but this tends to be when the DAC is better quality than the streamer. So, in this case I guess leaving the timing in the Aurender would be preferred. But try it. I would wait to get high end cables until after you have it in your system.