Not trash, no. Random bumps like that can be viewed as a sort of diffuser. Better than a flat wall. There's no such thing as a perfect room, especially not in a case like yours where it has to balance with sweet spot listening, background in the kitchen, etc.
Everyone wants the one and done solution, when really the only way to know for sure is try it and see. If you care about imaging, by far the most important factor there is symmetry. Set them up equidistant and symmetrical and if you like the imaging then you are done. Even here though, once again it is a balance. Toed in for the best imaging when sitting for serious listening might have to balance with how it sounds from the living room other times. Again no way to know other than try and see.
The other thing about location, speaker distance from walls affects tone and frequency response. Don't be distracted by the fireplace, there's always more than one thing going on. And, guess what? The only way to find out is set it up, listen, and see.
Only after trying and finding you hear some flaw, only then we work on the flaw. Until then it is all internet blah blah blah. Which we have in abundance! lol!
