Hi Bacardi - I have no direct experience with Wyred 4 Sound, so I can't offer you an opinion. Sorry.
I can certainly see the appeal in multiple mono amps. But I agree with Summitav's comment that...
Unless you are going to be building the SOA $40k multichannel music sound system, there is no need to use all monoblocs.
That is why I suggested a middle ground approach of 2 amplifiers: a higher quality one for the FR/FL, and a more affordable one for the center and surrounds.
I do think running seperate mono channels will have better seperation, dynamics, imaging and soundstage.
There is some truth to this, provided you are comparing amps of similar price/quality. Keep in mind, though, that some of the best amplifiers available at any price are stereo, not mono. In other words, amps that have channels sharing a single power supply and chassis are not always inferior to those that don't. It comes down to the particulars of the design.
With that in mind, I will reiterate that there are truly excellent multichannel amps available. Two that come to mind that I have direct experience with: The Anthem Statement P5 and the Parasound Halo A51. They are powerhouses with excellent sound quality. If they are out of your price range, you could consider the Anthem Statement A5 or Parasound Halo A52.
Three notable differences between these Anthem and Parasound amps that may be relevant to you, given your comments:
1. The Anthem Statement amps use multiple power supplies (2 power supplies in the A5; 5 power supplies in the P5). The Parasound Halo amps use a single power supply.
2. The Parasound Halo amps are class A for the first few watts. The Anthem Statement amps are not.
3. The Anthem Statement amps run much cooler (because of 2).
I have owned amps from both manufacturers and liked them both.