Most commercial speakers are not meant to be pointed directly at one's head, so they do sound better with little or no toe in for a wide variety of listening positions.
Generally there are 2 schools of thought. One, to use more directional speakers pointed into the room. This way as you get closer to one side you hear it less. I understand the theory but have never heard it used successfully.
The other approach is to make speakers with wide and even dispersion, and point them forward instead of in. I personally have heard this and like it. Magico and Revel are excellent examples of speakers that give a wide sweet spot with little toe-in.